NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme present in all living cells, functioning as a central mediator of cellular redox reactions and energy metabolism. In research contexts, NAD+ is studied for its role in sirtuin enzyme activation (SIRT1-7), poly(ADP-ribose) polymerase (PARP) activity, and mitochondrial biogenesis.
Preclinical studies have demonstrated NAD+ involvement in DNA damage repair mechanisms, circadian rhythm regulation via CLOCK/BMAL1 pathways, and age-associated mitochondrial dysfunction models. Research into NAD+ depletion and supplementation continues to advance our understanding of cellular senescence, oxidative stress responses, and longevity mechanisms at the molecular level.
NAD+ is also a subject of active investigation in the context of neurodegenerative disease models, inflammatory pathway modulation, and muscle function studies. It remains one of the most extensively researched coenzymes in contemporary longevity and cellular biology science.
Format: Lyophilised powder | Purity: ≥99% by HPLC | For Research Use Only
