Semax is a synthetic heptapeptide derived from the ACTH (4-7) Pro-Gly-Pro sequence, originally developed as a research tool for central nervous system and neurological studies. Its structural basis in the ACTH fragment confers neurotrophin-like activity without significant adrenocortical stimulation.
Preclinical research has demonstrated its neuroprotective properties following ischaemic injury models, as well as its capacity to increase brain-derived neurotrophic factor (BDNF) expression and modulate serotonergic and dopaminergic neurotransmission in neural tissue. Studies have also characterised its effects on nerve growth factor (NGF) and the neurotrophin receptor TrkB signalling pathway.
Research has explored Semax in cognitive performance assays in animal models, including working memory tasks, Morris water maze protocols, and spatial learning models, as well as in stress response modulation studies. It is of particular research interest as a non-stimulant nootropic model compound with a documented safety profile in preclinical investigations, making it a reference compound in the study of alternative neuroprotective and cognitive-modulating mechanisms.
Format: Lyophilised powder | Purity: ≥99% by HPLC | For Research Use Only
